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In three-dimensional space, V730 is located near the coactivator binding site 84 and, along with M734 and I737 in the hydrophobic groove, allows the formation of a smoother and flatter surface that permits greater complementarity to FxxLF compared with the LxxLL motif (Figure 7C)

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Chronic methionine overload can elevate homocysteine, a cardiovascular risk marker

doi: 10.3390/biom11111645 130

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