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When the V max values are set to 50% of their normal values, the number of functional hepatocytes decreases to 75% of normal after 20 hours (the blue curve)

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Cell Tissue Res 347:245256 Germoush MO, Mahmoud AM (2014) Berberine mitigates cyclophosphamide-induced hepatotoxicity by modulating antioxidant status and inflammatory cytokines