doi:10.1016/j.joim.2018.11.004
CR-activated cell cycle periodic genes in our study are directly or indirectly involved in tumorigenesis pathways, drive cancer cell proliferation and aggressiveness (RRM2, ACSL3, RBBP8, KMO, FKBP5), drug resistance (ABCC5) and modulate chemosensitivity (FKBP5) (references in Supplementary Table S2A)
More specifically, this may be observed with respect to certain genes, including Egr, Nos, Srf, Vegr, Akt1, Plc , and Kras genes (Vukojevic et al., 2018), all of which are responsible for the synthesis of factors necessary for a diverse set of processes
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Michailidou Z, Gomez-Salazar M, Alexaki VI