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GLP-1RAs have been shown to significantly reduce major adverse cardiovascular events (MACE) in individuals with T2DM, and even those with overweight or obesity without diabetes [2]

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The relatively high hazard ratios underscore the substantially elevated risk of NAION among semaglutide users compared to those prescribed non-GLP-1 RA medications for obesity and T2D

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If a patient gets good weight loss results from Zepbound, switching to Wegovy is unlikely to improve results