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Long-term hyperglycemia can contribute to persistent disturbances in glutamatergic signaling and neural damage in the medial prefrontal cortex, contributing to depressive behaviors [91]

This mechanism further supports the role of GLP-1RAs in blood pressure regulation and nephroprotection [87]

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When rapid weight loss is medically necessary : Before bariatric surgery, for joint replacement candidacy, or when weight directly threatens cardiovascular health

The upper abdomen the area between the belly button and the lower ribsis perfectly acceptable for GLP-1 injections