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Among 69,221 propensity-matched patients with IBD, those who had received a GLP-1 RA had a 5-year colorectal cancer incidence of 0.2% compared with 0.42% in non-GLP-1 RA users (OR, 0.49), corresponding to a 51% reduction in odds of developing colorectal cancer

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In addition, challenges like individual tolerability and competition from dual agonists, such as Eli Lillys tirzepatide, also demand further optimization [3537]

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