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At higher doses: Some participants experienced dysesthesia , an abnormal skin sensation Discontinuation rates were higher than placebo A portion of discontinuations were attributed to excessive weight loss , underscoring the importance of careful dosing and clinical oversight Additional late-stage trials are ongoing and will further clarify safety, tolerability, and optimal dosing strategies

A.GopalP.et al (2014)

Notably, sex-related differences in weight reduction became more pronounced with increasing degrees of weight loss and in trials with longer treatment durations [55]

Ipamorelin works through the GHRP/ghrelin receptor pathway, which represents a complementary but distinct mechanism

[DOI] [PubMed] [Google Scholar] 88.Salem MA, Ismail RS, Zaki HF, Arafa HMM, El-Khatib ASN