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Meanwhile these agents have the potential to reduce major adverse cardiovascular events (MACE) in patient with T2DM as a drug class, individual drugs have different potency and effects they need tailored approach to align with patient treatment goals rather than generalized use (117)

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GLP-1R agonists have shown potential benefits in muscle health by decreasing muscle atrophy and inflammation, as well as improving muscle microvasculature and endurance (68)