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Our companion paper, Evaluating Biometric Trend Drivers: How to reflect medical breakthroughs and other drivers in forward-looking assumptions, explores the practicalities for insurers in maintaining an up-to-date view on emerging biometric trend drivers such as AOMs and provides a framework for incorporating the insured mortality impacts into insured improvement bases

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This suggests that AD is more akin to a syndrome than a traditional disease, with its pathological presentation representing a convergence of pathogenic pathways [111]

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Research shows that approximately 10-15% of GLP-1 users experience suboptimal weight loss or weight regain, pointing to individual differences in medication response and lifestyle factors that deserve investigation