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Tabe Y, Jin L, Leysath CE, Kimura S, Kantarjian H, Andreeff M , Konopleva M

In low- and middle-income regions, where micronutrient deficiencies are highly prevalent, eggs have been promoted as a cost-effective and culturally acceptable intervention (130)

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In particular with the CRISPRa approach, the transcriptional activators that are fused to the dCas9 enzyme will increase the length of the construct, such that a combination of sgRNA and dCas9-transcriptional activators will be too large to load onto a single AAV vector