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However, JMJD-5 blocks H3K36me2 accumulation in the regions that are normally associated with this modification

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Analysis of publicly available gene expression datasets GSE3189 and GSE46517 showed lower expression, respectively, of both EPAC2 and TXNIP in melanoma compared to melanocytic nevi [64] and higher TXNIP mRNA expression in nevi and a progressive decrease in TXNIP mRNA levels in primary to metastatic lesions [65]