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Magarelli, the current medical consensus is that approximately 60-70% of cases treated inside a fertility clinic are due in part or in full to male factors

They concluded that while GHK-Cu does demonstrate anti-wrinkle effects in cellular studies, "there is a surprising absence of clinical studies using them." The review identified skin permeation as the central challenge: GHK's high aqueous solubility and low partition coefficient work against transdermal absorption