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The recommended use of metoclopramide, the only currently approved medication for gastroparesis in the United States, is for a duration of less than 3 months, due to the risk of reversible or irreversible extrapyramidal tremors

Additionally, oxidized glutathione (GSSG) reported a significant increase when both Salvia species were subjected to water stress, but decreased with increasing melatonin (Fig

This efficacy limitation, rather than safety concerns, halted further development

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