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Cardiovascular benefits of GLP-1 The SELECT trial demonstrated that GLP-1 therapy rapidly reduces heart attacks and strokes. These cardiovascular benefits have long been hinted at in diabetes trials, but the magnitude observed in SELECT surprised even seasoned cardiologists

This irritancy test approach may be extended to other similar compounds or minerals and can potentially predict the in vivo skin irritation response before conducting clinical testing on human subjects

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The liver has long been considered as a principal site responsible due to most of the phase I and phase II metabolism reactions occur with liver metabolic-enzymes participation

& Tena-Sempere, M