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Alcohol and other substance use disorders are common, and clinicians should be prepared to recognize them, just like hypertension and diabetes
The genetic variants, carried by roughly 10% of the general population, cause a surprising and still mysterious phenomenon that researchers refer to as GLP-1 resistance, in which levels of the hormone GLP-1 (glucagon-like peptide-1), which helps regulate blood sugar, are higher but less biologically effective
While formulations differ in dosing frequency, onset, and tolerability, they show broadly comparable safety and efficacy
Related Stories Scientists discover 70 existing drugs that block deadly hantavirus infections Semaglutide outperforms other GLP-1 drugs for weight loss in psychiatric populations Why new Alzheimers drugs are dividing regulators worldwide Options include once-weekly injectables, daily agents, combination therapies with insulin, and newer oral formulations that some patients may prefer, although tolerability and discontinuation remain considerations
