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Jamil Alkhaddo, M.D., endocrinologist and medical director at the Weight Watchers affiliated medical group

Empty stomach dosing: Oral semaglutide must be taken on an empty stomach with a 30-minute wait before eating, while injectable semaglutide does not have this requirement

In non-industry sponsored analyses, net costs per quality-adjusted life year have ranged from $237,000-$483,000 [79], with low cost-effectiveness related to plateauing of weight benefits but continued costs of treatment, as well as weight regain following any cessation of use

However, many subgroup differences were not statistically significant, and results should be interpreted with caution given the limited number of included studies for several analyses