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GLP-1 is a very important hormone but the trouble is that it is a very short lived hormone and it is produce in very small amounts and it doesnt last very long as there are enzymes that break it down

These trials include more than 2,050 participants across diverse regions, and the first major results from TRANSCEND-T2D-1 are expected to be presented at the American Diabetes Association Scientific Sessions in June, then published in a peer-reviewed journal

This schedule works because the compound has a long half-life that allows sustained hormone receptor activation

Table 12: Results at Week 24 (LOCF*) in an Active-Controlled Trial of Dapagliflozin Initial Combination Therapy with Metformin HCl Extended-Release in Adults with Type 2 Diabetes Mellitus Dapagliflozin Add-On To Metformin HCl Immediate-Release A total of 546 adult patients with type 2 diabetes mellitus with inadequate glycemic control (HbA1c 7% and 10%) participated in a 24-week, placebo-controlled trial to evaluate dapagliflozin in combination with metformin HCl (NCT00528879)

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