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you feel full sooner and for longer, and 2) a disruption of the dopamine receptor, meaning the good feeling of eating something that you enjoy is not as rewarding

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A prospective quantitative study of sensory deficits after whole sural nerve biopsies in diabetic and nondiabetic patients: surgical approach and the role of collateral sprouting

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For example, the deletion of the core clock gene Bmal1 in the mouse brain led to astrocyte activation - an established marker of brain and neuronal injury - as well as synaptic degeneration [179]