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doi: 10.2174/1570159X20666220327222921 45 van HamerenG.MuradovJ.MinarikA.AboghazlehR.OrrS.CortS.et al
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67 Non-proliferative astrogliosis typically occurs in neural tissue that is responding to a pathology but is not overtly damaged and retains its basic tissue architecture, for example (i) during diffuse neuroinflammation caused by peripheral exposure to microbial antigens such as lipopolysaccharide (LPS), 68,69 (ii) in tissue regions that are at a distance from focal lesions (diaschisis) caused by stroke, trauma or autoimmune attack, 8,70 or (iii) in tissue undergoing neurodegenerative changes
Gain of potential detrimental functions or effects could include: (i) increased pro-inflammatory signalling which at first is adaptive but can also be chronic and contribute to excess inflammation and degeneration 152,153
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