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Put simply, GSH is subject to destruction in the acid environment of the stomach

d , In vitro stability assay of GIPMK-801 ( n = 2) incubated in human plasma or PBS, pH = 7.4 ( n = 1)

This is because we want good nutrients coming in to avoid losing nourishment as your body will ask for less food than usual and the risk could be that you intake less nourishment than you need

This approval represents the first FDA-approved drug specifically targeting mitochondrial function, establishing regulatory precedent for the mitochondrial dysfunction pathway in aging and neurodegeneration