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The results of several large randomized controlled trials indicated that maintaining blood glucose at near normal concentrations was the most important step in limiting the risk of diabetic neuropathy and lower extremity amputation (70-72)

When dermal papilla signaling weakens through aging, hormonal changes, or inflammation follicles progressively miniaturize

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For comparison, the FDA's 2003 guidance on pharmacokinetics in patients with impaired hepatic function recommends that drugs primarily cleared by the liver undergo dedicated studies across Child-Pugh categories A, B, and C [9]

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