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Epigenetic alterations

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The CJC-1295 (No-DAC) component (CAS 863288-34-0) is a synthetic analog of the N-terminal 1-29 fragment of human GHRH bearing four stabilizing substitutions (D-Ala at position 2, Gln at 8, Ala at 15, and Leu at 27) that reduce enzymatic cleavage by dipeptidyl peptidase-IV and endopeptidases relative to the native sequence