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It may sound high, but in reality, only a small percentage is absorbed

Journal of Translational Medicine, 21 , 36

They are simply not there yet

Cyanocobalamin is a synthetic form of vitamin B12 used by licensed healthcare professionals in the management of vitamin B12 deficiency and related clinical situations

Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists