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MHT = Menopausal Hormone Therapy The first-line treatment for menopause, the combination of systemic estrogen and a progestogen is FDA-approved to treat symptoms such as hot flashes, night sweats, Genitourinary Syndrome of Menopause (GSM), and aid in the prevention of osteoporosis

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10.1016/j.cmet.2014.09.018 46 ForetzM.GuigasB.ViolletB

Considering TNF-, a type II transmembrane protein with an intracellular N terminus and signalling potential both as a membrane-integrated protein and a soluble cytokine released after proteolytic cleavage [386, 387], the activation of its receptor (TNFR) led to the recruitment of intracellular adaptor proteins that activate multiple signal transduction pathways [387, 388]

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