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This dynamic regulation allows active Vitamin D to intervene during the later stages of T cell activation, where VDR binds to Vitamin D response elements (VDREs) in the genome, reshaping the T cell transcriptional landscape and modulating cytokine expression, migratory behavior, and metabolic programming [160,161,162]

Deformity or angle of bending was measured as the angle of deflection of the laser beam that was refracted from a small mirror fixed at the end of the bone

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