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There is no human evidence that it controls cravings, and the broader metabolic benefits were not universal

Thirty-three participants were divided into two groups and received a daily dose of 2 g of DHA or a placebo for 18 months

For instance, 5-HT is a neurotransmitter associated with mood and behavioral inhibition, and elevated levels can lead to increased feelings of fatigue, a phenomenon known as the central fatigue hypothesis. As shown in Figure 1b, 5-HT in the brain is metabolized from tryptophan through tryptophanase (TYH)

Laboratory investigation

Safety findings showed a consistent gastrointestinal adverse-event burden across treatments, with relative risks ranging from 1.33 to 1.91