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Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with OZEMPIC [see CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS ]

Tirzepatide activates both GLP-1 and GIP receptors and may produce slightly greater weight loss in some patients

The process of metformin exerting its extensive effects cannot be separated from the regulation of gut microbiota

We further performed doxycycline-inducible expression of oxygen-dependent NADPH oxidase (NOX) in the cytosol (TPNOX) or mitochondria (mitoTPNOX) to deplete compartmentalized NADPH, as described previously 30 , and tested the cellular sensitivity to glucose starvation (Extended Data Fig