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To explore the functional role of FOXO4 in senescence, its expression was silenced using siRNA in TM3 Leydig cells prior to H2O2-induced senescence

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The ratio of diameter change compared with the original size was 0.69 0.02, 0.72 0.02, 0.73 0.04, and 1.35 0.03 in control, 1.0 g/ml BPC 157, 100 g/ml BPC 157 and 200 M SNP, respectively (Fig