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Representative drugs like the highly selective HIF-2 antagonist Belzutifan (MK-6482) [488] inhibit the expression of pro-angiogenic and pro-survival genes, alleviating abnormal metabolic burden and vascular disruption in tumor tissues

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Management strategies include eating smaller meals, avoiding fatty foods, staying hydrated, and using ginger-based remedies

Neither alone can reduce the signal as much as both together

Eligible publications were limited to articles and reviews written in English and published between 2020 and 2025