"Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA." The New England Journal of Medicine, 2023
Full-dose GLP-1 therapy can sometimes be associated with low energy during early use
Patients generally seem happy with their GLP-1 injections
Lessons from bariatric surgery: Can increased GLP-1 enhance vascular repair during cardiometabolic-based chronic disease
Furusawa and colleagues found that butyrate produced by obligate anaerobic bacteria improved colitis by promoting histone H3 acetylation in the promoter and conserved non-coding sequence regions of the Foxp3 locus, thereby supporting differentiation of T reg cells and enhancing intestinal immune tolerance (84)