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Unfortunately two phase I studies of the anti-IFN antibody AMG811 in the treatment of mild to moderate systemic and cutaneous lupus (113) showed safety with favorable immunogenicity profile but did not show significant therapeutic effect despite decreasing IFN-related gene expression (114)

XY: Methodology, Writing original draft, Investigation

Emerging evidence on the pathobiology of mucositis

once daily) is added on the 8th day

ROS damages the genetic code of the enzymes involved in transmethylation and transsulfuration and increases the degradation of GSH and the free radical hydrogen sulfide (H2S) produced