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They are targeting the same molecular pathway that purpose-built migraine drugs target
Practical Considerations Identifying patients who can benefit from GLP-1 RAs remains in the hands of the clinician
The combination with GLP-1 also appears to reduce the gastrointestinal side effects that sometimes limit GLP-1 only treatments, improving tolerance and long-term adherence
5.3 Cost and Access Are Not Mechanism Problems The most common reason patients discontinue GLP-1 therapy is cost
Immediate Consultation Triggers Contact your healthcare provider promptly if you experience: severe or persistent vomiting, signs of dehydration that do not resolve with increased fluids, severe abdominal pain (especially right upper quadrant, which may indicate gallbladder issues), symptoms of pancreatitis (severe pain, nausea, vomiting), or any other concerning symptoms
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