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This theory is often referred to as the methyl trap hypothesis. In simple terms, folate may help improve certain blood markers associated with anemia even when vitamin B12 levels remain low

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High-dose folinic acid (Leucovorin) therapy provides a proven treatment strategy for restoring brain folate levels while minimizing disruption to methylation balance

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SAM is involved in hundreds of methylation reactions throughout the body, and the systemic effects of preserving SAM through NNMT inhibition in tissues beyond adipose tissue remain unknown