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Tolerance to the anorexiant effects of phentermine usually develops within a few weeks of starting therapy

Conversely, the extrinsic pathway of apoptosis is initiated by the binding of death ligands to death receptors, which activates downstream effector caspase-8, ultimately resulting in the activation of caspase-3, -6, and 7, thereby inducing direct cell death [94]

NLRP3-inflammasome activating DAMPs stimulate an inflammatory response in glia in the absence of priming which contributes to brain inflammation after injury

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