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Similarly, as a result of the positive findings from the recent DAPA-CKD trial [90], dapagliflozin is now indicated for the treatment of CKD, and can be initiated if eGFR 25 ml/min/1.73 m 2

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93,94,95,96 Advancements in carrier technology and nucleic acid modification techniques have led to significant progress in overcoming these challenges, as exemplified by the first siRNA drug, patisiran (Onpattro), which has been approved for treating hereditary transthyretin-mediated amyloidosis by degrading mRNA encoding transthyretin (TTR)