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GHK-Cu and Skin Biology Research In vitro studies with human adult dermal fibroblasts found that GHK-Cu at concentrations of 0.01, 1, and 100 nM increased production of both elastin and collagen, with all concentrations increasing TIMP1 a key inhibitor of matrix metalloproteinases

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Comp Biochem Physiol B Biochem Mol Biol 121(1):4956 Mentlein R, Gallwitz B, Schmidt WE (1993) Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide- 1(736)amide, peptide histidine methionine and is responsible for their degradation in human serum

The study was based only on data from the published literature, did not allow for prospective or randomized controlled trials, and did not explore the direct associations between drug penetration ratios and adverse fetal or neonatal outcomes