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This receptor selectivity profile is the key pharmacological distinction between the two analogues, and makes MT-1 the reference compound in studies focused specifically on the MC1R/pigmentation axis without the confounding MC3R (energy homeostasis) and MC4R (appetite, sexual function) activity associated with MT-2

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Commonly reported side effects in clinical trials included nausea, vomiting, diarrhea, constipation, abdominal pain, headache, fatigue, dizziness, bloating, belching, hair loss, and dry mouth