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Fluid retention & GI: GH-axis stimulation can cause water retention, joint aches or mild nausea/GI discomfort

Studies in GHD patients receiving hGH therapy report [15]: Improved quality of life 2-5% increase in lean muscle mass 7-10% lower fat mass and a -1.2inch mean decrease in waist circumference 11-16% lower LDL (bad) cholesterol Yet, the benefits of hGH therapy in otherwise healthy individuals appear to be more modest

L., Wu, H.-M., Hong, C.-J

Similar results were seen in the REWIND study were dulaglutide also reduced the risk of nonfatal strokes compared to placebo

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