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For competitive athletes, use could result in suspension or disqualification if detected in a doping control

These adaptations are mediated by increased mitochondrial biogenesis, enhanced insulin sensitivity, stimulation of anabolic pathways, and the release of myokines such as irisin, apelin, and IL-6, which promote muscle remodeling and systemic metabolic improvements (32)

This reaction is catalyzed by mitochondrial 1-hydroxylase (CYP27B1), producing 1,25-dihydroxyVitamin D [1,25(OH)D], the biologically active form of Vitamin D [94, 95]

Any decline in redox enzymes may increase free radical generation with subsequent induction of lipid peroxidation, protein oxidation, and DNA/RNA degradation 557,558,559

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