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PDAC uses BCKAs secreted by CAFs as substrates for BCAAs synthesis or increases the oxidative metabolic flux of BCKA in a BCKDH-dependent mode

3 COMT inhibitors, such as entacapone, opicapone, and tolcapone, and MAO-B inhibitors, such as selegiline, rasagiline, and safinamide, work by enhancing levodopas duration of action with inhibition of their respective enzymes

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Supply Chain and Go-to-Market Trends Supply chain strategies are evolving to support rapid category growth: Expansion of co-manufacturing and formulation capabilities Partnerships with ingredient suppliers for protein and fiber systems Investment in cold-chain and convenience food logistics Growth of digital and direct-to-consumer distribution models These strategies enable scalability while maintaining product consistency and innovation speed