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Lignans often play roles in plant defense mechanisms against pathogens and environmental stress (Adlercreutz 2007)

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Mitochondrial dysfunction may induce OS, mtDNA damage and related mutations, epigenetic alterations, spindle assembly defects, meiotic errors, chromosomal misalignments, and telomere shortening, which may lead to a decrease in oocyte quantity and quality [8,9,10,11]