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28 Beyond the tendency toward allergic sensitization (atopy), specific genes affecting mast cell behavior (TPSAB1, KIT), histamine breakdown (HNMT, AOC1), and methylation (MTHFR) are inherited

First, while the rescue experiments with ferric citrate and NAC strongly support an iron deficiency and ROS-mediated mechanism, the absence of established positive controls, such as the iron chelator deferoxamine (DFO) or direct ROS generators, precludes a definitive comparative conclusion that the observed effects are uniquely attributable to CGAs iron-chelating activity

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The cut-off points for these tertiles were meticulously determined based on the distributions among the control subjects

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