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Medscape (2023)

When can I restart my GLP-1 medication after surgery

Insulin resistance in insulin-sensitive tissues can lead to increased insulin secretion by pancreatic -cells, but the final result is that -cells cannot meet the increased demand for insulin

SGLT2 inhibitorrelated adverse effects, including genital mycotic infections, volume depletion, and rarely ketoacidosis, remain clinically relevant and should be considered when these agents are prescribed as part of combination therapy and importantly, the intrinsic risk of hypoglycemia with combined GLP-1 receptor agonist and SGLT2 inhibitor therapy is low because neither class directly stimulates insulin secretion in a glucose-independent manner and when hypoglycemia occurs, it is more commonly related to concomitant insulin or sulfonylurea use rather than the combination itself [41, 42, 44]