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Early IDD (radiographically mild degeneration or early symptomatic discs) is characterized by subtle bioenergetic stress with a mild decline in m and increased mitochondrial ROS (MitoROS), preceding overt cell loss and ECM collapse

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10.1016/j.bbi.2018.01.009 97 KoelleD

Contact Dermatitis, 34: 106-110

However, medications used for the domiciliary management of early symptoms, notwithstanding their importance, have not been and are not presently regarded with the same attention and seriousness