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Freund, A., Orjalo, A

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The specific phyto-component affecting the enzyme system is not identified yet, but in the study, Aloe vera gel directly affects key enzymes such as 3 HSD, reducing enzyme activity and modulating the pathway toward estradiol formation [102]

Loomba R, Neutel J, Mohseni R et al (2019) LBP-20-VK2809, a Novel Liver-Directed Thyroid Receptor Beta Agonist, Significantly Reduces Liver Fat with Both Low and High Doses in Patients with Non-Alcoholic Fatty Liver Disease: A Phase 2 Randomized, Placebo-Controlled Trial