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Alterations in the normal function of excitatory amino acid carrier 1 affect cysteine transport and GSH synthesis impairing zinc homeostasis (the thiol group of GSH can function as a principal Zn 2+ chelator for the maintenance of Zn 2+ homeostasis in neurons) and oxidative stress, enhancing susceptibility to ischemia-induced neuronal cell death in the hippocampus (162164)

Preparation of DTNB stock solution: Dissolve 0.01 mol/L DTNB in 0.05 mol/L phosphate buffer (pH 7.0) to prepare the DTNB stock solution

Biochem Biophys Res Commun

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Molecular basis of glutathione synthetase deficiency and a rare gene permutation event