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Low thyroid function, cortisol dysregulation, low testosterone, estrogen imbalance, and perimenopausal hormone changes can all contribute to stubborn weight gain and fatigue

A 2026 systematic review and meta-analysis found that around half of people with fibromyalgia experience symptoms of depression or anxiety

These include the dose of each medication, any pre-existing health conditions, and the overall health of the person taking them

Proceedings of the National Academy of Sciences of the United States of America 111 , 37633768, doi: 10.1073/pnas.1320393111 (2014)

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