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( We list all final C-APC exclusion categories for CY 2026 in Addendum J to this final rule with comment period (which is available via the internet on the CMS website at )

Collectively, these findings indicate that non-selective or excessive chelation of brain iron may disrupt physiological metallostasis, emphasizing the need for precisely titrated, brain-targeted anti-ferroptotic interventions with balanced efficacytoxicity profiles. Beyond traditional chelators, several natural compounds have also shown potential in regulating iron transport proteins

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Lipid-modulate activity of Cichorium glandulosum Boiss

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