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Caution is warranted in patients with a history of pancreatitis, severe gastrointestinal disease including gastroparesis, or diabetic retinopathy

Recent research has underscored the importance of AMPK in managing metabolic conditions, including diabetes, obesity, and fatty liver disease (Sbastien and Reuben, 2017)

Following the catabolism of glucose in the cytoplasm as part of glycolysis, the generated pyruvate is transported to the mitochondrial matrix, where it feeds into the TCA, undergoing oxidation to reduce NAD + to NADH, which is the main electron donor of the ETC 87

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