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Additionally, oxidative stress can impair the clearance mechanisms of A, including autophagy and proteasomal degradation, contributing to its accumulation [154]

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Despite its importance, vitamin B12 deficiency is surprisingly common, particularly in the UK, where it affects around 6% of people under 60 and up to 20% of those over 60

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This article compares the two as research compounds: what each one is, the mechanisms each is investigated for, how their preclinical research profiles differ, and why they are sometimes examined together

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